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Gen 6:3 : Hayflick Limit

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Author Topic: Gen 6:3 : Hayflick Limit  (Read 87 times)
Mark
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« on: September 15, 2016, 12:59:40 am »

Here is something i just learned that totally verifies the Bible!! I'm just astonished that i have not heard of this until now.

Gen 6:3
And the LORD said, My spirit shall not always strive with man, for that he also is flesh: yet his days shall be an hundred and twenty years.


The Bible states that our life span will be 120 years. Here is scientific proof, that we can only live to 120 years.  Cheesy

Lust for life: breaking the 120-year barrier in human ageing

In rich countries, more than 80% of the population today will survive past the age of 70. About 150 years ago, only 20% did. In all this while, though, only one person lived beyond the age of 120. This has led experts to believe that there may be a limit to how long humans can live.

Animals display an astounding variety of maximum lifespan ranging from mayflies and gastrotrichs, which live for 2 to 3 days, to giant tortoises and bowhead whales, which can live to 200 years. The record for the longest living animal belongs to the quahog clam, which can live for more than 400 years.

If we look beyond the animal kingdom, among plants the giant sequoia lives past 3000 years, and bristlecone pines reach 5000 years. The record for the longest living plant belongs to the Mediterranean tapeweed, which has been found in a flourishing colony estimated at 100,000 years old.

Some animals like the hydra and a species of jellyfish may have found ways to cheat death, but further research is needed to validate this.

The natural laws of physics may dictate that most things must die. But that does not mean we cannot use nature’s templates to extend healthy human lifespan beyond 120 years.
Putting a lid on the can

Gerontologist Leonard Hayflick at the University of California thinks that humans have a definite expiry date. In 1961, he showed that human skin cells grown under laboratory conditions tend to divide approximately 50 times before becoming senescent, which means no longer able to divide. This phenomenon that any cell can multiply only a limited number of times is called the Hayflick limit.

Since then, Hayflick and others have successfully documented the Hayflick limits of cells from animals with varied life spans, including the long-lived Galapagos turtle (200 years) and the relatively short-lived laboratory mouse (3 years). The cells of a Galapagos turtle divide approximately 110 times before senescing, whereas mice cells become senescent within 15 divisions.

The Hayflick limit gained more support when Elizabeth Blackburn and colleagues discovered the ticking clock of the cell in the form of telomeres. Telomeres are repetitive DNA sequence at the end of chromosomes which protects the chromosomes from degrading. With every cell division, it seemed these telomeres get shorter. The result of each shortening was that these cells were more likely to become senescent.

Other scientists used census data and complex modelling methods to come to the same conclusion: that maximum human lifespan may be around 120 years. But no one has yet determined whether we can change the human Hayflick limit to become more like long-lived organisms such as the bowhead whales or the giant tortoise.

What gives more hope is that no one has actually proved that the Hayflick limit actually limits the lifespan of an organism. Correlation is not causation. For instance, despite having a very small Hayflick limit, mouse cells typically divide indefinitely when grown in standard laboratory conditions. They behave as if they have no Hayflick limit at all when grown in the concentration of oxygen that they experience in the living animal (3-5% versus 20%). They make enough telomerase, an enzyme that replaces degraded telomeres with new ones. So it might be that currently the Hayflick “limit” is more the Hayflick “clock”, giving readout of the age of the cell rather than driving the cell to death.

The trouble with limits

The Hayflick limit may represent an organism’s maximal lifespan, but what is it that actually kills us in the end? To test the Hayflick limit’s ability to predict our mortality we can take cell samples from young and old people and grow them in the lab. If the Hayflick limit is the culprit, a 60-year-old person’s cells should divide far fewer times than a 20-year-old’s cells.

But this experiment fails time after time. The 60-year-old’s skin cells still divide approximately 50 times - just as many as the young person’s cells. But what about the telomeres: aren’t they the inbuilt biological clock? Well, it’s complicated.

When cells are grown in a lab their telomeres do indeed shorten with every cell division and can be used to find the cell’s “expiry date”. Unfortunately, this does not seem to relate to actual health of the cells.

It is true that as we get older our telomeres shorten, but only for certain cells and only during certain time. Most importantly, trusty lab mice have telomeres that are five times longer than ours but their lives are 40 times shorter. That is why the relationship between telomere length and lifespan is unclear.

Apparently using the Hayflick limit and telomere length to judge maximum human lifespan is akin to understanding the demise of the Roman empire by studying the material properties of the Colosseum. Rome did not fall because the Colosseum degraded; quite the opposite in fact, the Colosseum degraded because the Roman Empire fell.

Within the human body, most cells do not simply senesce. They are repaired, cleaned or replaced by stem cells. Your skin degrades as you age because your body cannot carry out its normal functions of repair and regeneration.
To infinity and beyond

If we could maintain our body’s ability to repair and regenerate itself, could we substantially increase our lifespans? This question is, unfortunately, vastly under-researched for us to be able to answer confidently. Most institutes on ageing promote research that delays onset of the diseases of ageing and not research that targets human life extension.

Those that look at extension study how diets like calorie restriction affect human health or the health impacts of molecules like resveratrol derived from red wine. Other research tries to understand the mechanisms underlying the beneficial effects of certain diets and foods with hopes of synthesising drugs that do the same. The tacit understanding in the field of gerontology seems to be that, if we can keep a person healthy longer, we may be able to modestly improve lifespan.

Living long and having good health are not mutually exclusive. On the contrary, you cannot have a long life without good health. Currently most ageing research is concentrated on improving “health”, not lifespan. If we are going to live substantially longer, we need to engineer our way out of the current 120-year-barrier.

http://theconversation.com/lust-for-life-breaking-the-120-year-barrier-in-human-ageing-14911
« Last Edit: September 15, 2016, 01:30:42 am by Mark » Report Spam   Logged

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« Reply #1 on: November 08, 2016, 01:37:04 am »

Scientists Admit Limit to Human Life Span

Researchers from the Albert Einstein College of Medicine have concluded the maximum human life span has a ceiling of about 115 years—and we’ve already reached it. The researchers analyzed data from the International Database on Longevity and the Human Mortality Database, which compiles mortality and population statistics from more than 40 countries. Since the 19th century, average life expectancy has continued to rise…. Demographers and biologists traditionally believed the increase in maximum life span would not end soon. “But our data strongly suggest that it has already been attained and that this happened in the 1990s.”

(WNS)–Scientists are just beginning to believe what the Bible tells us in Genesis 6:3. “Then the Lord said, ‘My Spirit shall not abide in man forever, for he is flesh: his days shall be 120 years.’” With that, God declared there would be no more Methuselahs, and new research published in the journal Nature is bearing that out.

Researchers from the Albert Einstein College of Medicine have concluded the maximum human life span has a ceiling of about 115 years—and we’ve already reached it.

The researchers analyzed data from the International Database on Longevity and the Human Mortality Database, which compiles mortality and population statistics from more than 40 countries. Since the 19th century, average life expectancy has continued to rise. Those born in America in 1900 could only expect to live a short 47 years. Today that figure has risen to nearly 79 years. Since the 1970s, the age to which the oldest people live also has risen.

Demographers and biologists traditionally believed the increase in maximum life span would not end soon.

“But our data strongly suggest that it has already been attained and that this happened in the 1990s,” Jan Vijg, senior author of the new research, said in a statement.

According to the study, the percentage of people who survive to old age, defined as 70 and older, increases with their calendar year of birth, suggesting a continuing increase in average life expectancy. But when the researchers analyzed data from 1900 on, they found the life span of people who live beyond one century peaks at about 100 and then declines rapidly no matter the year of birth. In other words, for people who managed to collect 100 candles on their birthday cakes, the average life expectancy peaked right around that birthday, whether they were born in 1800 or 1900.

“This finding indicates diminishing gains in reducing late-life mortality, and a possible limit to human lifespan,” Vijg said.

Next the researchers analyzed data for people who have lived to be 110 or older in the four countries with the largest number of people who have attained that age—the United States, France, Japan, and the United Kingdom. Between 1968 and 2006, the average age at death for these people increased rapidly between the 1970s and early 1990s but plateaued around 1995, further evidence of a lifespan limit. The researchers also calculated the chance of any one person anywhere in the world living to age 125 is less than 1 in 10,000.

To date, the oldest living person in modern recorded history, other than in early Biblical accounts, was Jeanne Calment, a 122-year-old French woman who died in 1997. The oldest man was Jiroemon Kimura of Japan, who died in 2013 at the age of 116.

Although medical advances against infectious and chronic diseases may continue to boost average life expectancy, the researchers do not believe the maximum life span will increase.

“Such advances would need to overwhelm the many genetic variants that appear to collectively determine the human life span,” Vijg said.

http://theaquilareport.com/scientists-admit-limit-to-human-life-span/
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« Reply #2 on: December 13, 2016, 12:03:54 pm »

http://www.msn.com/en-us/news/good-news/oldest-american-adele-dunlap-of-new-jersey-turns-114/ar-AAlv2FV?li=BBmkt5R&ocid=spartandhp
Oldest American, Adele Dunlap of New Jersey, turns 114
12/13/16



PITTSTOWN, N.J. — The New Jersey woman who is the oldest American is another year older.

Adele Dunlap received balloons, and fellow residents at the Country Arch Care Center in Pittstown on Monday sang "Happy Birthday" to the 114-year-old.

But The Record (http://bit.ly/2hocF0w ) reports Dunlap didn't appreciate the fuss. Asked what she was thankful for, Dunlap said, "Gee, how should I know?" As for a birthday wish, she responded, "I've never thought of such a thing. I don't wish for anything."

She also said it was her 105th birthday. The nursing staff and her family say it's her habit to shave about a decade off her age.

Dunlap became the country's oldest person in July following the death of Goldie Michelson, of Worcester, Massachusetts.
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« Reply #3 on: December 19, 2016, 07:25:13 pm »

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« Reply #4 on: March 20, 2017, 03:34:25 pm »

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